Active Ingredient: Diltiazem Hydrochloride (120mg) in a sustained-release (SR) formulation.
What it does: It is a non-dihydropyridine calcium channel blocker. The sustained-release mechanism allows for a gradual and even release of diltiazem, helping to dilate blood vessels, improve oxygen supply to the heart muscle, and control heart rate smoothly throughout the day.
Prescribed for: Long-term prevention and management of chronic stable or vasospastic chest pain (angina pectoris), treatment of mild-to-moderate high blood pressure (essential hypertension), and prevention of certain fast heart rhythms (supraventricular tachyarrhythmias).
Dosage & Administration
Standard Regimen: Typically 120mg taken twice daily (every 12 hours) in divided doses. Dose adjustments are made based on response up to a typical daily maximum of 360mg (elderly up to 240mg daily).
Important Rules: Take your doses at the same times every day to maintain stable blood levels. It can be taken with or without food.
Strict Administration Rule:Swallow the tablet whole. Do not crush, chew, or split it, as doing so destroys the sustained-release matrix, causing a rapid and dangerous release of the entire dose into your system.
Do Not Stop Abruptly: Never stop taking this medication suddenly, particularly if you are treating angina. Abruptly halting can cause a rebound of severe chest pain or a dangerous blood pressure spike.
Dietary Warning:Do not drink grapefruit juice while on this medication. Grapefruit raises the concentration of diltiazem in your blood, which can lead to severe side effects.
Contraindications & Warnings
When NOT to use: Do not take this medication if you have a very slow heart rate (bradycardia), sick sinus syndrome, second- or third-degree AV block (without a functioning pacemaker), severe low blood pressure (systolic under 90 mmHg), acute heart failure, or fluid in the lungs (pulmonary congestion).
Interactions: Avoid taking this medicine with other drugs that slow your heart rate or affect cardiac conduction (such as beta-blockers, amiodarone, or digoxin) without close doctor supervision. It can also increase the blood levels of certain cholesterol-lowering statins (like atorvastatin or simvastatin).
Side Effects
Headache, dizziness, fatigue, and sudden flushing or warmth in the face.
Swelling of the ankles or lower legs (peripheral edema).
Nausea, constipation, or mild indigestion.
Warning Signs: Contact your healthcare provider immediately if you experience a dangerously slow heartbeat, severe dizziness, fainting, or swelling that rapidly worsens.