SIGLIMET XR 50/1000

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Description:

SIGLIMET XR 50MG/1000MG Tablet contains Sitagliptin 50 mg (as Sitagliptin Phosphate Monohydrate) and Metformin Hydrochloride 1000 mg (extended-release). Manufactured by Square Pharmaceuticals PLC, it is an extended-release, dual-action oral antidiabetic combination that pairs a DPP-4 inhibitor (Sitagliptin) with a higher dose of a biguanide (Metformin) to enhance glycemic control through complementary mechanisms.

Uses:

Management of type 2 diabetes mellitus as an adjunct to diet and exercise to improve blood sugar control in adults requiring higher metformin dosage.
Helps decrease hepatic glucose production, reduce intestinal absorption of glucose, and increase insulin release while suppressing excess glucagon secretion in a glucose-dependent manner.

Dose:

Adults: Typically taken once daily with a meal, preferably in the evening, to reduce potential gastrointestinal discomfort.
Dosage must be individualized by a physician based on current treatment regimen, effectiveness, and tolerability, without exceeding the maximum daily dose (100 mg Sitagliptin / 2000 mg Metformin).
Swallow whole; do not crush, chew, or split the extended-release tablet. Use strictly as prescribed by a healthcare professional.

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